Cisplatin and aki and autophagy

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August undefined, 2024

WebMar 5, 2024 · The ability of cisplatin (cis‐diamminedichloroplatinum II) toxicity to induce acute kidney injury (AKI) has attracted people's attention and concern for a long time, but its molecular mechanisms are still widely unknown. Web1 day ago · In this study, a natural product from Osage Orange, pomiferin, was identified as a novel autophagy activator that circumvents innate resistance by triggering autophagic cell death via SERCA inhibition and activation of the CaMKKβ-AMPK-mTOR signaling cascade. In addition, pomiferin also directly inhibited the P-gp (MDR1/ABCB1) efflux and ...

Pharmacological inhibitors of autophagy have opposite effects in …

WebIn AKI mice induced by injection of a single dose of cisplatin (15 mg/kg), oral administration of kaempferide (50 mg/kg) either before or after cisplatin injection markedly improved renal function, and ameliorated renal tissue damage. WebNov 1, 2024 · Toll‐like receptor 2 (TLR2) is constitutively expressed in tubular epithelial cells of the kidney and participates in cisplatin‐induced AKI. The autophagy is a dynamic catabolic process that maintains intracellular homeostasis, which is involved in the pathogenesis of AKI. iphone repair free

Autophagy in proximal tubules protects against acute kidney injury

WebJan 10, 2024 · Cisplatin, a chemotherapeutic agent approved by the United States Food and Drug Administration in 1978, is used in the treatment of various solid organ malignancies [ 13 ]. However, ~30% of... WebCisplatin-induced acute kidney injury in mice was established by intraperitoneal injection of cisplatin. The levels of urea nitrogen and creatinine in serum were measured， renal pathology change was assayed by HE staining， qRT-PCR and Western blot were used to detect the expression levels of PIM1 mRNA and PIM1 protein. iphone repair grand rapids

Pathophysiology of Cisplatin-Induced Acute Kidney Injury

Canagliflozin protects against cisplatin-induced acute kidney injury …

WebOct 13, 2024 · Cisplatin-induced acute kidney injury (AKI), characterized by rapid loss of renal function within days of initiating treatment, occurs in around 30% of patients who are receiving cisplatin ... WebJan 22, 2024 · Cisplatin treatment may activate toll-like receptors 2 in renal tubular cells, which further activates autophagy via the phosphorylate phosphoinositide 3-kinase … orange county regional park passesWebNov 3, 2024 · The kidney injury caused by cisplatin can present in a variety of ways. As it was clearly proved in some researches, the most serious and common damage induced by cisplatin is acute kidney injury (AKI) … iphone repair gratiot

"WebApr 27, 2024 · Aims:Cisplatin, an anticancer drug, always leads to nephrotoxicity by causing mitochondrial dysfunction. As a major mechanism for cellular self-degradation, autophagy has been proven to protect against cisplatin … " - Cisplatin and aki and autophagy

Cisplatin and aki and autophagy

Mechanisms of Cisplatin-Induced Acute Kidney Injury: Pathological ...

WebAug 17, 2024 · NEW & NOTEWORTHY This study examined how inhibition of autophagy has opposite effects on the development of acute and chronic kidney injury. Autophagy … WebSep 1, 2014 · Pharmacologic induction of autophagy by administrating the mTOR inhibitor, rapamycin or temsirolimus, facilitated renal recovery from AKI during endotoxemia in aged mice [116,119] and pharmacologic inhibition of autophagy with either bafilomycin or 3-methyladenine enhanced cisplatin-induced renal tubular cell death .

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WebDec 7, 2024 · Genetic ablation of the renal tubular (RT) Atg7 gene or pharmacological inhibition of autophagy suppressed the protective effects of HDAC6. Taken together, our study indicates that HDAC6 contributes to ischemia- and cisplatin-induced AKI by inhibiting autophagy and the acetylation of α-tubulin. WebAug 6, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and …

WebSep 25, 2024 · (1) Autophagy inhibits inflammatory responses induced in AKI through the regulation of mTOR and AMPK pathways and the inhibition of inflammasomes activation. (2) Autophagy can also help in the regulation of inflammatory responses through the nuclear factor kappa B pathway, which is beneficial to the recovery of kidney tissues. WebNov 26, 2024 · The inhibition of cisplatin-induced autophagy increases cisplatin-induced apoptosis, suggesting the synergistic induction on cancer cell death via inhibiting cisplatin-induced autophagy activity [39,43]. Thus, through the inhibition of chemotherapy-induced autophagy, ginkgolic acids can enhance the sensitivity of cancer cells to chemotherapy.

WebJul 7, 2024 · The nephrotoxicity of cisplatin remains a major hurdle in the field of oncology. 30% of patients treated with cisplatin develop acute kidney injury (AKI) and all patients … WebAcute kidney injury (AKI) is a heterogeneous group of critical disease conditions with high incidence and mortality. Vasoconstriction, oxidative stress, apoptosis, and inflammation are generally thought to be the main pathogenic mechanisms of AKI. Ferroptosis is a type of iron-dependent nonapoptotic cell death characterized by membrane lipid peroxide …

WebAutophagy is a conserved multistep pathway that degrades and recycles damaged organelles and macromolecules to maintain intracellular homeostasis. The …

WebMay 30, 2024 · In this study, we detected a persistent autophagy activation in mouse kidneys after nephrotoxicity of repeated low dose cisplatin (RLDC) treatment. 3-methyladenine (3-MA) and chloroquine (CQ), respective inhibitors of autophagy at the initiation and degradation stages, blocked autophagic flux and improved kidney repair in … iphone repair glen allen short pumpWebDec 17, 2024 · In cisplatin-induced acute kidney injury (AKI) or nephrotoxicity, autophagy is rapidly induced in renal tubular … orange county refinance ratesWebThe delivery of an approved agent such as rapamycin in a PFC NP format enhances local delivery and offers a novel mechanism-based prophylactic therapy for cisplatin-induced acute kidney injury. For nearly five decades, cisplatin has played an important role as a standard chemotherapeutic agent and been prescribed to 10–20% of all cancer patients. … orange county redistricting mapWebAutophagy is induced in proximal tubules during cisplatin nephrotoxicity in C57BL/6 mice C57BL/6 mice (male, 8–10 weeks old) were injected with 25mg/kg cisplatin or saline as control. (A) After the indicated time, kidneys were harvested to collect cortical and outer medulla tissues for immunoblot analysis of LC3 and β-actin (loading control). orange county register alex patterson hockeyWebAdministration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been … iphone repair gratiot and 12 mileWebFeb 2, 2024 · Some scholars have found that in the cisplatin-induced AKI mice, the C. cicadae mycelium extract regulated the inflammatory response by inhibiting renal pathological changes, inflammatory cell infiltration, and the release of a variety of inflammatory cytokines such as TNF-α, IL-1β, and IL-6. iphone repair great neckWebThe apoptosis induced by cisplatin in mice increased evidently compared with the control group, which was decreased in the mice with neferine pretreatment. What' more, we found that autophagy increased obviously in mice pretreated by neferine contrast to … orange county regional chamber of commerce