Cthrc1 fibrosis
WebFibrosis is mainly triggered by inflammation in various tissues, such as heart and liver tissues, and eventually leads to their subsequent dysfunction. Fibrosis is characterized … WebFeb 22, 2007 · We identified collagen triple helix repeat containing-1 (Cthrc1) ... G. Normal and pathologic soft tissue remodeling: role of the myofibroblast, with special emphasis on liver and kidney fibrosis. Lab Invest. 2003; 83: 1689–1707. Crossref Medline Google Scholar;
Cthrc1 fibrosis
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WebSep 30, 2016 · CTHRC1 (collagen triple-helix repeat-containing 1), a protein secreted during the tissue-repair process, is highly expressed in several malignant tumors, including pancreatic cancer. We recently ... WebAug 7, 2024 · Fibroblasts also have important pathophysiological and pathological functions, e.g., in wound contraction and tissue fibrosis 5,6,7. ... (marked also by C1qtnf3 and Cthrc1) ...
Web顾健人 中国 上海交通大学医学院 中国工程院院士 Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-beta.. 19. WebMay 18, 2024 · Collagen triple helix repeat containing-1 (CTHRC1) is a highly conserved extracellular matrix glycoprotein that is overexpressed in two murine models of cholestatic liver fibrosis. Elevated CTHRC1 has been found to attenuate liver fibrosis in these murine models, thus we aimed to study the expression of CTHRC1 in patients with cholestatic …
Webfibrosis, in which the activation of hepatic stellate cell (HSCs) is considered as the central event, the role of CTHRC1 remain un- clear and need to be investigated.
WebDec 8, 2024 · Fibrosis is characterized by fibroblast dysfunction and excessive deposition of cell-matrix that affect the normal functioning of the original tissue or organ. 1 ... (CD90) and CTHRC1, were gradually activated in pseudotime from non-lesion to lesion regions (Figure S3G,H). To clarify the factors regulating CTHRC1+ fibroblasts, we implemented ... ina 274c meaningWebJun 6, 2012 · CTGF is a secreted matricellular protein with very complex biology. It has been shown to modulate many signaling pathways leading to cell adhesion and migration, angiogenesis, myofibroblast activation, and extracellular matrix deposition and remodeling, which together lead to tissue remodeling and fibrosis. It has been reported in the … ina 245 i physical presenceWebDec 23, 2004 · Collagen triple helix repeat containing 1 (Cthrc1) was identified in a screen for differentially expressed sequences in balloon-injured versus normal arteries. Cthrc1 expression was not detectable in … imyfone free downloadWebMay 13, 2024 · CTHRC1 is highly expressed in patients with primary CRC and hepatic metastasis of CRC and predicts a poor prognosis. To … ina 212 d 13 waiverWebCollagen triple helix repeat containing 1 (CTHRC1), a glycoprotein, is involved in multiple pathological processes, including inflammation and fibrosis. However, the function of CTHRC1 in asthma ... ina 245 a adjustment of statusWebTreatment of cholestatic fibrosis by altering gene expression of Cthrc1: Implications for autoimmune and non-autoimmune liver disease Author links open overlay panel Zhaolian Bian a 1 , Qi Miao a 1 , Wei Zhong a 1 , Haiyan Zhang a , Qixia Wang a , Yanshen Peng a , Xiaoyu Chen a , Canjie Guo a , Li Shen a , Fan Yang a , Jie Xu a , Dekai Qiu a ... imyfone free trialWebFibrosis is mainly triggered by inflammation in various tissues, such as heart and liver tissues, and eventually leads to their subsequent dysfunction. Fibrosis is characterized by the excessive accumulation of extracellular matrix proteins (e.g., collagens) produced by myofibroblasts. The well-developed actin cytoskeleton of myofibroblasts, one of the main … ina 291 burden of proof