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Hotair overexpression

WebOct 1, 2024 · Based on the overexpression of HOTAIR in a variety of human cancers, technologies related to its utility as a useful target for early cancer detection and treatment are rapidly developing, such as the liposome-encapsulated antisense oligonucleotide probe 99 m Tc-HYNIC-ASON targeting HOTAIR for its in vivo imaging in malignant GBM … WebNext, HOTAIR overexpression was transfected into H9c2 cells and exposed to H/R. qRT-PCR results showed that HOTAIR overexpression attenuated the up-regulation of miR-17-5p expression induced by H/R . Western blot verified that HOTAIR overexpression partially reversed H/R-induced down-regulation of p-STAT3 expressions ( Figure 4B and C ).

Unique role for lncRNA HOTAIR in defining depot-specific gene ...

WebHow much is a hot air balloon ride? Hot air balloon rides vary based on the company, location, and add-ons. With that being said, the average cost of a hot air balloon ride is … WebMar 30, 2024 · BisPhenol A, diethylstilbesterol, and IRF1 promote the overexpression of HOTAIR by binding to the corresponding gene promoter elements. Bisphenol A and diethylstilbesterol independently interact with estrogen receptors in the cytoplasm, translocate into the nucleus, associate with the methyl transferases MLL1 and MLL3, bind … burlingame weather monthly https://typhoidmary.net

HOTAIR: a potential metastatic, drug-resistant and prognostic …

WebHOTAIR is highly expressed in metastatic breast cancers. High levels of expression in primary breast tumours are a significant predictor of subsequent metastasis and death. This is partially due to HOTAIR-mediated overexpression of the HER2 oncogene through sequestration of miR-331-3p, which is a negative regulator of HER2 expression. WebNon-coding RNAs are emergent elements from the genome, which do not encode for proteins but have relevant cellular functions impacting almost all the physiological processes occurring in eukaryotic cells. In particular, microRNAs and long non-coding RNAs (lncRNAs) are a new class of small RNAs transcribed from the genome, which modulate … WebJul 15, 2024 · HOTAIR is a long noncoding RNA (lncRNA) which serves as an important factor regulating diverse processes linked with cancer development. Here, we used comprehensive identification of RNA-binding proteins by mass spectrometry (ChIRP-MS) to explore the HOTAIR-protein interactome. We were able to identify 348 proteins interacting … halo of edema

HOTAIR: an oncogenic long non-coding RNA in different cancers

Category:Frontiers Long Non-coding RNA HOTAIR Function as a …

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Hotair overexpression

Cells Free Full-Text Deciphering the Long Non-Coding RNAs and ...

WebMar 30, 2024 · Nevertheless, overexpression of FUS can partially reverse the effect of overexpression of HOTAIR on Cyclin D1 and p21, while overexpression of SIRT3 can … WebTo verify the above observation, HOTAIR plasmid was conducted, as shown in Fig. 2B, overexpression of HOTAIR significantly increased CD11b expression in HL-60 cells, indicating an enhancement of myeloid differentiation, but not in NB4, U937, and THP-1 cell lines. Interestingly, we overexpressed HOTAIR in HL-60 cells but without ATRA treatment ...

Hotair overexpression

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WebFeb 7, 2024 · Downregulation of HOTAIR was detected in osteosarcoma, which predicted poor prognosis of patients with osteosarcoma. Moreover, cell migration, invasion, and proliferation were suppressed by HOTAIR overexpression in osteosarcoma. Furthermore, LPR5 was a direct target of HOTAIR, which was upregulated in osteosarcoma. WebJul 11, 2024 · Overexpression of HOTAIR (HOTAIR OE, presented in figures as HOTAIR clone) and its effect on c-Met expression were analyzed and confirmed with confocal …

WebOverexpression of HOTAIR (HOX antisense intergenic RNA) is significantly correlated with tumor progression and poor prognosis in human ovarian cancer. However, the underlying mechanisms are largely unknown. In the present study, we investigated the roles of HOTAIR in the initiation and chemoresistan … WebApr 28, 2014 · Furthermore, HOTAIR overexpression promoted the proliferation, migration and invasion of gastric carcinoma cells, while HOTAIR depletion inhibited both cell …

WebAlso, overexpression of HOTAIR promoted the migration and invasion ability of lung cancer cells, confirmed by wound healing assay and transwell assay, which was suppressed by overexpression of miR-149-5p. Furthermore, dual-luciferase reporter assay indicated that miR-149-5p could bind both HOTAIR and the 3’UTR of HNRNPA1. WebOverexpression of HOTAIR is associated with metastasis in multiple cancers, including breast, pancreatic, lung, hepatocellular carcinoma, and colorectal [19,154–157]. HOTAIR …

WebNov 28, 2024 · To create the A783U mutant HOTAIR overexpression plasmid, staggered QuikChange oligos AG66/AG67 were used to generate the A783U mutation in pTRE3G-HOTAIR using the QuikChange Site Directed Mutagenesis Kit (Agilent 200519) to generate pTRE3G-A783U_HOTAIR. A 1.6 Kb fragment of A783U mutant HOTAIR was amplified with …

WebSep 13, 2024 · Overexpression of HOTAIR increased the expression of CSC-related biomarkers and was correlated with Klf4 expression, which could be used as a promising therapeutic target. A year later, another ... burlingame veterinary clinicWebMay 20, 2024 · Overexpression of HOTAIR in HASMCs was confirmed using qRT-PCR (Fig. 2a). miR-126 expression was significantly reduced in the HOTAIR overexpressed HASMCs compared to the control group (Fig. 2a). As shown in Fig. 2 b and c, HOTAIR overexpression markedly attenuated Pi-induced calcium deposition and calcium nodules formation in … burlingame veterinary hospitalWebDec 29, 2024 · A valuable new mouse model was developed for studying the functional effects of overexpressing HOTAIR and the mechanism of action of HOTAIR, and used to demonstrate overexpression of HOTAIR promoted breast cancer metastasis to the lung. Mechanistically, HOTAIR overexpression changed the chromatin from a closed, inactive … burlingame weather caWebMay 5, 2024 · HOTAIR regulates genes related to key depot-specific pathways in hASCs. HOTAIR is one of the most differentially expressed transcripts between GF and ABD hASCs (Divoux et al. 2024), and its role in adipogenesis was suggested by our previous overexpression study (Divoux et al. 2014).Additionally, prior studies in several cancer … burlingame veterinary clinic topeka ksWebJan 17, 2015 · HOTAIR overexpression is also related to hepatocellular carcinoma (HCC)40-43. In an experiment, Ding et al.44 showed that suppression of HOTAIR leads to the … halo of a spiral galaxyWebMay 21, 2012 · HOTAIR is a long intervening non-coding RNA (lincRNA) that associates with the Polycomb Repressive Complex 2 (PRC2) and overexpression is correlated with poor survival for breast, colon and liver ... burlingame weather forecast 10 dayWebDec 6, 2024 · HOTAIR overexpression enhanced, whereas its knockdown reduced, cell proliferation, cachexia-associated pro-inflammatory cytokine expression, and muscle atrophy. Cachexia-associated symptoms were ameliorated in mice bearing Hotair-knockdown bladder tumors undergoing cisplatin treatment. We demonstrate for the first … burlingame weather 10 day