Sin3b cancer

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August undefined, 2024

Webb11 nov. 2014 · We concluded that Sin3B was required for both KRas-induced senescence and inflammation in vivo, and that entry into senescence surprisingly correlated with … Webb1 jan. 2016 · Sin3B also interacts with an E3 ubiquitin ligase, RNF220 that targets Sin3B for ubiquitination and promotes its proteasomal degradation (Kong et al., 2010). Recently …

Search: SIN3B - The Human Protein Atlas

Webb29 aug. 2024 · This finding reveals a largely unexplored function for Sin3b in the nervous system. Sin3 is not essential for viability in S. cerevisiae (Sternberg et al., 1987) but Drosophila sin3 and murine Sin3a and Sin3b mutants are lethal (Pennetta and Pauli, 1998; Cowley et al., 2005; Dannenberg et al., 2005; David et al., 2008; Sharma et al., 2008 ). WebbExpression of SIN3B (KIAA0700) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. We use cookies to enhance the usability … rail repairs schedule

Zebrafish sin3b mutants are viable but have size, skeletal, and ...

Webb13 aug. 2012 · We show that Sin3A is downregulated in a variety of human tumors and that Src, JNK, RhoA and PP1B/β-Catenin are regulated in a manner analogous to our … Webb5 aug. 2015 · SIN3A and SIN3B, which lack intrinsic DNA-binding activity, serve as molecular scaffolds that bridge interactions between chromatin regulators and … Webb8 aug. 2014 · In leukemia cells and fibroblasts, Sin3b silencing led to Myc up-regulation, whereas Sin3b overexpression induced Myc deacetylation and degradation. An analysis of Sin3b expression in breast tumors revealed an association between low Sin3b expression and disease progression. rail return edinburgh to derby

Chromatin-Associated Protein SIN3B Prevents Prostate Cancer …

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Webb1 apr. 2007 · Sin3B expression is required for cellular senescence and is up-regulated upon oncogenic stress. 23: 24691445: 2014: Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression. 21: 20547842: 2010: Interference with Sin3 function induces epigenetic reprogramming and differentiation in breast cancer … Webb14 aug. 2024 · Oncomine expression analysis using two independent studies showed that SIN3B is significantly downregulated in carcinoma compared to normal prostate tissue, and that SIN3B lies among the top 10% most downregulated transcripts in prostate cancer (ranked 1,384 out of 22,238 genes and 83 out of 8,603 genes, respectively) (Fig. 6A, B). rail record oldWebb1 okt. 2024 · SIN3B has been implicated in the initiation of senescence in vitro. Here we show that in a mouse model of prostate cancer, SIN3B provides a barrier to malignant progression. SIN3B was required for … rail return tickets

"Webb12 aug. 2009 · Importantly, expression of Sin3B increases upon oncogenic stress, both in vitro and in vivo, correlating with the induction of the senescence program, but is … " - Sin3b cancer

Sin3b cancer

Chromatin-Associated Protein SIN3B Prevents …

Webb1 juli 2008 · These observations strongly suggest that Sin3B plays an essential role in coordinating the chromatin modifying activities required for the transient repression of pro-proliferation genes in... WebbHuman hepatocellular carcinoma (HCC) is the sixth most common cancer and the fourth leading cause of cancer-related death worldwide, and the incidence of HCC has been on the rise in recent decades. [ 1 , 2 ] Current treatment options include liver transplantation or surgical resection, while first-line chemotherapeutic agents include sorafenib, lenvatinib, …

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Webb8 aug. 2014 · As Sin3b is also required for transcriptional repression by Mxd-Max complexes, our results suggest that, at least in some cell types, Sin3b limits Myc activity … Webb29 sep. 2014 · While Sin3B is dispensable for cell survival and proliferation in primary fibroblasts, it is required for entry into quiescence upon serum withdrawal, and for entry into cellular senescence...

WebbSin3B was associated with delayed PDAC progression and correlated with an impaired inflammatory response. In murine and human pancreatic cells and tissues, levels of … Webb24 jan. 2024 · Here, we report that the chromatin-associated Sin3B protein is necessary for HSCs’ commitment to differentiation, but dispensable for their self-renewal or survival. ... Cancer Biology (9351) Cell Biology (13518) Clinical Trials (138) Developmental Biology (7517) Ecology (11524) Epidemiology (2066) Evolutionary Biology (15317)

WebbExpression of SIN3B (KIAA0700) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. We use cookies to enhance the usability of our website. If you continue, we'll assume that you … Webb9 apr. 2024 · Innovate through Integrated Solutions Home; Contact Us; English Deutsch; 日本語; 简体中文; Products. Product Browser; Product Discounts & Benefits

Webb8 dec. 2024 · Sin3B is required for the senescent phenotype and elevated levels of reactive oxygen species elicited upon Bmi-1 depletion. Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression interaction with Sin3B influences Na (v)-channel trafficking or stability in the membrane. rail rider roof rackWebbSin3A/B are global transcription regulators that provide a versatile platform for diverse chromatin-modifying activities. Sin3 proteins regulate key cellular functions that include … rail ridership uk rail rickets booking offerWebbSubcellular - SIN3B - The Human Protein Atlas SIN3B SUBCELLULAR RNA EXPRESSION HUMAN CELLS ANTIBODIES AND VALIDATION Dictionary Nucleoplasm Plasma membrane Subcellular proteome Nucleoplasm Plasma Membrane All non detected compartments SIN3B detected in Nucleoplasm and Plasma membrane ASSAYSi rail ridership in singaporeWebb11 nov. 2014 · SIN3B, the SASP, and pancreatic cancer Cellular senescence is classically considered a tumor suppressive mechanism. In addition to having stably exited the cell … rail river bistroWebbWe previously demonstrated that the histone deacetylase-associated protein SIN3B is essential for oncogene-induced senescence in cultured cells. Here, using a mouse model … rail road ferry waalhavenWebbSIN3B. The antibodies are designated mAB for monoclonal and pAb for polyclonal. The release of the Human Protein Atlas in which the antibody was first published. All assays through which the antibody has been validated. Assays&annotation provide a detailed description of the different assays. The pie-charts indicate degree of validation. rail road flat post office